It was third time lucky for Tsitsipas who had twice lost in the Dubai final, against Roger Federer in 2019 and Novak Djokovic a year later.
18-year-old Carlos Alcaraz of Spain became the youngest to clinch an ATP 500 title at the same event on Sunday when he defeated Diego Schwartzman in the final of the Rio Open.
World number one Carlos Alcaraz cruised past Frenchman Arthur Fils 6-2, 6-1 to win the Qatar Open on Saturday and extend his perfect start to the year.
Daniil Medvedev has called for a streamlined ATP calendar with only Grand Slams and Masters 1000 tournaments offering ranking points, though the Russian concedes such reforms would be difficult to implement.
Twice ATP Finals champion Alexander Zverev booked his place in the season-ending championship after progressing to the semi-finals of the Vienna Open on Friday, marking his eighth qualification in the past nine seasons.
Daniil Medvedev was awarded the Dubai Tennis Championships title after his opponent Tallon Griekspoor withdrew due to an injury he suffered in the semi-finals.
Doubles is not a sideshow: Yuki Bhambri on re-invention and right support
The bonus amount, a 177% increase on the previous season's payout, will be distributed to players based on performance at the nine ATP 1000 tournaments, which rank just below the four Grand Slams in prestige.
Alcaraz off to winning start at ATP Finals with win over De Minaur
Jannik Sinner and Carlos Alcaraz are poised to reignite their rivalry at the ATP Finals, with the year-ending championship that begins on Sunday expected to produce another title showdown between the pair in a season that has belonged to them.
Carlos Alcaraz began his bid for a first ATP Finals trophy with a win over Alex de Minaur and Alexander Zverev overpowered Ben Shelton in their round-robin openers.
Dhakshineswar Suresh is the nation's new Davis Cup hero, having led India to a historic 3-2 Davis Cup win over The Netherlands on Sunday.
The Indo-Japanese wild card pair displayed remarkable grit to upset Harrison and King 4-6, 6-3, 18-16 in a match that kept the crowd on the edge of their seats.
Just nine days after his loss to Fritz, which snapped his 13-match unbeaten streak, the world number one defeated the American 6-4, 6-4 in straight sets, capping an incredible debut at the ATP 500 event and securing his career-best 67th season win, continuing a dream season.
Japan Open: Alcaraz marches into quarterfinals, hails "best physio in the world" after overcoming ankle issues
Sinner will face 19-year-old Learner Tien for the title.
Eighth seed Machac, who won gold in mixed doubles at the Paris Olympics, became the third player from his country to win an ATP 500 title, following Tomas Berdych and Radek Stepanek.
World number two Carlos Alcaraz beat seventh seed Arthur Fils 6-2, 6-4 on Saturday to advance into his third Barcelona Open final, where the Spaniard will face Denmark's Holger Rune for the title.
His previous best was 97 in February, which he had attained after winning the Chennai Open, an ATP Challenger series event.
France's Boisson wins first WTA title in Hamburg
Carlos Alcaraz avoided another scare at the Queen's Club ATP 500 event as the top-seeded Spaniard dispatched France's Arthur Rinderknech with little fuss 7-5, 6-4 to reach the semi-finals on Friday.
Yuki Bhambri and his Australian partner Alexei Popyrin snatched victory from the jaw of defeat to triumph in the men's doubles at the Dubai Tennis Championships.
Rohan Bopanna and his Croatian partner Ivan Dodig suffered a shock loss to the pair of Francisco Cerundolo and Nicolas Jarry in the first round match of the China Open.
Iga Swiatek was the latest top player to suffer an upset loss in Montreal as the Wimbledon champion
Alex De Minaur rallied from a set down and saved three match points to claim the Washington Open title after beating Alejandro Davidovich Fokina in the final of the ATP 500 event.
Alexander Zverev was heckled by a spectator during Friday's Munich Open quarter-final and the top seed asked the chair umpire to eject the individual who alluded to domestic abuse allegations against the German.
Jannik Sinner became the first Italian to win the ATP Finals title following a dominant 6-4, 6-4 victory over American Taylor Fritz.
24-year-old Sebastian Baez, who is looking to become the first two-time Rio Open champion, will take on Alexandre Muller after the Frenchman beat Francisco Comesana 7-5, 6-7(3), 6-3 in a marathon battle.
Teichmann wins singles, Anshba-Pridankina claim doubles at Mumbai Open
As the spotlight shines on Carlos Alcaraz's title defence and Novak Djokovic's pursuit of a record 25th Grand Slam, a determined group of challengers is quietly preparing to shake up the draw.
Yuki Bhambri and his Dutch partner Robin Hasse went down in straight sets to Ivan Dodig and Austin Krajicek at the Dubai Duty Free Tennis Championships.
Top seed Carlos Alcaraz withstood a charge from qualifier Luca Nardi for a 6-1, 4-6, 6-3 victory in the second round of the Qatar ExxonMobil Open in Doha on Wednesday.
Shelton blasted an ace on match point to seal the win and avenge his five-set loss to Tiafoe at last year's U.S. Open as the 22-year-old continues to make strides in his breakout season.
Yuki Bhambri made his first doubles semi-finals of the ATP 500 tour.
Ace Indian tennis player Sumit Nagal was off to a winning start in Monte Carlo Masters as he defeated world number 63 Flavio Cobolli of Italy in straight sets in the qualifiers in Monte Carlo on Saturday.
The Serbian Wimbledon champion extended his win streak to nine, wrapping up the final in 75 minutes without facing a break point and booked his place at next month's ATP Finals.
Britain's Cameron Norrie fought back from a set down to beat world number two Carlos Alcaraz 5-7, 6-4, 7-5 in the Rio Open final on Sunday.
India's Yuki Bhambri and his French partner Albano Olivetti crashed out of Marrakech Open after losing the hard-fought semifinal to second seeds Lucas Miedler and Alexander Erler of Austria.
Djokovic's official website also confirmed his participation in the Dubai tournament.
Italian Bracciali banned for life, Starace for 10 years